uropod

Uropods, in immunology, refer to the hind part of polarized leukocytes, mostly involved in cell-to-cell interaction, cell activation and apoptosis. Leukocyte polarization is an important requirement for migration, activation and apoptosis.

Microtubule retraction into the uropod and its role in T cell polarization and motility
Neutrophil traction stresses are concentrated in the uropod during migration.
Type I PIP Kinase Is a Novel Uropod Component that Regulates Rear Retraction during Neutrophil Chemotaxis
Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration
Ca-dependent myosin II activation is required for uropod retraction during neutrophil migration. J Cell Sci
Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration.
Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and function.
Phospholipid flip-flop and phospholipid scramblase (PLSCR 1) co-localize to uropod rafts in fMLP stimulated neutrophils
Lee, J.H. et al. Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J. Cell Biol. 167, 327-337
Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutr...